Selective accumulation of cytosol CDP-choline as an isolated erythrocyte defect in chronic hemolysis.
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چکیده
منابع مشابه
CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.
Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing. Others showed that CDP-choline liposomes significantly increased brain uptake over the free drug in cerebral ischemia models. Liposomes were formulated as DP...
متن کاملCharacterization of human erythrocyte choline transport in chronic renal failure.
BACKGROUND Membrane transport of choline cations is elevated in renal failure in erythrocytes and cerebral tissue but the origins and clinical importance of this are unknown. METHODS The membrane transport changes have been characterized using erythrocytes from patients on maintenance haemodialysis (HD), patients on continuous ambulatory peritoneal dialysis (CAPD), and control subjects. Data ...
متن کاملReply: Beneficial effects of exogenous CDP-choline (citicoline) in EAE.
Sir, We read with great interest the comment of Dr Grieb that two independent groups previously investigated the effects of CDP-choline (citicoline) on the course of EAE in Lewis rats and found beneficial effects of the substance. The results were presented at scientific meetings by Clayton et al. (1999) and Grieb et al. (2004). However, the results were not published as research papers and thu...
متن کاملBeneficial effects of exogenous CDP-choline (citicoline) in EAE.
Sir, I read with great interest the article by Skripuletz et al. (2015), who showed beneficial effects of exogenously applied CDP-choline (citicoline) in murine myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) and in cuprizone-induced mouse model of demyelination. I would like to congratulate the authors for their report, which already has been recogni...
متن کاملCDP-choline: neuroprotection in transient forebrain ischemia of gerbils.
CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. The ability of CDP-choline to alter phospholipid metabolism is an important function in the treatment of ischemic injury. Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially ar...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.10.3081